Dr. P.C. Huang
Joint-Appointed Faculty
Professor, Biophysics

Johns Hopkins University
Department of Biophysics
3400 North Charles Street
Baltimore, MD 21218
410-516-2015 Office
410-516-4118 Fax
phuang@welchlink.welch.jhu.edu

Bioinformatics, Genomics and Proteomics

Our research interest focuses on the organization and regulation of stress inducible genes and their gene products. More specifically, studies involve a family of proteins named metallothionein, which bind transition metals avidly. Metallothionein encoding genes are inducible by metals and other stress conditions. Thus this family of proteins may have a role in metal homeostasis and detoxification. The approaches used in our studies thus encompass the use of recombinant DNA technology, cloning and site-directed mutagenesis techniques, protein engineering methodology, molecular simulation and computational biology.

Major recent findings include the isolation and characterization of metallothionein genes from rice, Arabidopsis, and procine. Other accomplishments centered around the elucidation of metal binding preference by sequence motifs through mutagenesis using transgenic systems and in silico.

(Dr. Huang no longer accepts graduate students.)

Selected Publications: